Beilstein J. Org. Chem.2022,18, 217–224, doi:10.3762/bjoc.18.25
of enantioselectivity, and the corresponding optically active oxyaminated malonamates were obtained in reasonably good yields.
Keywords: enantioselective; malonamate; nitroso aldol reaction; N-selectivity; Takemotocatalyst; Introduction
Nitrosoarenes are versatile building blocks frequently
with nitrosoarene which provides facile access to chiral hydroxyamino malonamates having a quaternary carbon stereocenter (Scheme 1).
Results and Discussion
Initially, we chose the Takemotocatalyst to promote the model reaction between methyl N-bromophenyl-α-methylmalonamate (1a) and nitrosobenzene
takes place to afford the nitroso aldol product.
Conclusion
In summary, an efficient organocatalytic asymmetric nitroso aldol reaction of α-methylmalonamate has been reported. The reaction utilizes the well-known Takemotocatalyst, and this protocol demonstrates for the first time the use of malonamate